DES Daughters (Women exposed to DES in utero) face various reproductive tract abnormalities and higher cancer risks, notably clear cell adenocarcinoma (CCA) of the vagina and cervix. They have about 40 times the risk of developing CCA compared to unexposed women, with approximately 1 in 1,000 having developed this cancer. Up to 30%-35% of DES daughters have structural anomalies like a T-shaped uterus or cervical malformations, leading to high rates of infertility and poor pregnancy outcomes, including miscarriage, ectopic pregnancy, preterm labour, and stillbirth.

DES Daughters are twice as likely to experience infertility and pregnancy loss and are 50% more likely to undergo premature menopause. Research indicates modestly higher breast cancer risk after age 40, though findings are inconsistent. Other vulnerabilities include elevated risks of cervical precancerous changes and cardiovascular issues, such as high blood pressure and heart disease. Specialised gynaecologic care is recommended for DES Daughters, including annual exams and monitoring for abnormal tissue changes.

If you’ve been affected and want to connect with others who understand what you’re going through, we encourage you to join a private and supportive Facebook group — run and moderated by a DES Daughter. It’s a safe space where you can share your experiences, ask questions, and find solidarity. You can also help us understand your situation better by completing our confidential client questionnaire.

Fill in our client questionnaire

Your voice matters, and we’re here to support you every step of the way.